Updated April 2026

Best This Week in Startups Episodes

The top This Week in Startups episodes ranked by insight density. AI-powered summaries from Jason Calacanis — preview any episode in 5 minutes.

20episodes ranked
5 minper summary
Business, Technology, Startups

Top 20 Episodes Ranked

1
Mar 27, 2026•10 key insights

The $60 billion resource hiding in space, and the startup trying to mine it | E2268

  • •The $60 billion asteroid hiding 10 million miles away—and how one startup plans to mine it for $10.4M per mission
  • •They use lasers and magnets to extract platinum group metals from space rocks. Here's the wild part: it could have 90...
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2
Mar 26, 2026•10 key insights

This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

  • •This Bittensor subnet could cut drug discovery costs in HALF—turning a $2.6B process into something drastically cheaper
  • •65 billion possible molecules to search through, but miners are finding the best candidates in real-time using AI
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3
Mar 24, 2026•10 key insights

32 Million Dollar Fraud? Delve Scandal | E2266

  • •The $32M Delve fraud scandal: 500 boilerplate compliance reports with identical errors across different companies—bas...
  • •How to spot fraud before you invest: The one question that separates liars from hustlers—and why a 30-minute demo wou...
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4
Mar 21, 2026•10 key insights

The Drone Company Everyone Thought Was Illegal (Now Worth $4B+) | E2265

  • •How a 20-person startup with zero aviation experience convinced Rwanda to let them deliver blood by drone (and it sav...
  • •The 2am call that changed everything: blood delivered to a hospital roof instead of the mailbox—and a nurse had to cl...
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5
Mar 19, 2026•10 key insights

How Robinhood became a $68B company w/ Vlad Tenev

  • •How Vlad pitched investors on a $0 TAM with a $0 revenue model: 'Your TAM is zero and your revenue model is zero'
  • •The brutally stupid answer that almost killed the deal: 'Why do we have to make money?'
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6
Mar 17, 2026•10 key insights

Are Brain-Computer Interfaces Actually Ready for Humans? | E2263

  • •Brain-computer interfaces are finally leaving the lab—Paradromics is implanting their first patients in the next 4-8 ...
  • •The shocking truth about BCIs: micro-wires smaller than human hairs can decode what you're trying to say directly fro...
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7
Mar 14, 2026•10 key insights

This Decentralized Cloud is Thousands of Times Cheaper Than AWS | EP 2262

  • •The surprising reason why decentralized storage is 'thousands of times cheaper' than AWS—and how miners are already p...
  • •They built the first subnet to have its own blockchain—here's why the Bit Tensor ecosystem needed it
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8
Mar 10, 2026•10 key insights

How agents will change banking forever | E2260

  • •How a Shopify CEO just proved AI can improve itself: +19% performance gains in 8 hours with zero ML experience
  • •The shocking reason why AI is now LESS popular than ICE in America—46% of Americans actively oppose it
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9
Mar 10, 2026•10 key insights

The Global Expansion of Self-Driving Vehicles

  • •The $10M power infrastructure problem nobody's talking about: Getting utilities to provision 3-5 megawatts takes 12-1...
  • •Why Tesla's FSD improved 2X in just 18 months—and why that speed terrifies the industry
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10
Mar 7, 2026•10 key insights

Wisdom of the $TAO: the future is decentralized AI

  • •The $100M annual subsidy that's turning stranded talent worldwide into AI millionaires—no VC needed
  • •How a coding co-pilot built for $10M on Bit Tensor is crushing Cursor's $29B valuation at 5-7x cheaper
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